Parry's artic exploration began in 1818 when he received command of the brig Alexander in the artic expedition under Captain John Ross. This expedition followed the coast of Baffin Bay but was to turn around at the north end of Baffin Island at the entrance to Lancaster Sound. Parry was later to be given command of a new expedition returning to Lancaster Sound, in HMS Hecla accompanied by HMS Griper. Parry headed straight for Lancaster Sound and passed the point at which John Ross previously turned back. Blocked by heavy ice they went south for more than 100 miles into Prince Regent Inlet before turning back. Continuing for 600 miles, west of Lancaster Strait they won an award of £5,000 offered by Parliament. Finally, blocked by ice they turned back to a place called Winter Harbour on the south shore of Melville Island and remained there at anchorage for the next 10 months. It was not until August 1820 that the ship was allowed to resume sail in open water and they returned to reach England in October 1820, having lost only one crew member. Parry's voyage which had taken him through the Parry Channel three-quarters of the way across the Canadian Artic Archipelago was probably the single most productive voyage in the quest for the North West passage.
In April, 1821 Parry again left for the Artic commanding HMS Fury accompanied by HMS Hecla. The aim this time was to find a passage near the northwest end of Hudson Bay. The expedition had limited success but paved the way for a final voyage in 1824. In April 1824, Parry left London in command of HMS Hecla accompanied by HMS Fury. The goal this time was Prince Regent Inlet at the west end of Baffin Island a place were they had previously been stalled from progressing further by heavy ice. It was a bad year for ice and he did not reach Lancaster Sound until 10 September. He entered Prince Regent inlet but afyer 60 miles of ice he was forced to winter at place called Port Bowen. In late July 1825 they freed themselves from the ice but 60 miles further south they were caught in strong gales which forced Fury against the western shore causing considerable damage. After beaching the ship to attempt repairs it was revealed that the keel was broken and advancing ice forced them to abandon further efforts. Most of the stores were left on the beach with the crew of the Fury joining HMS Hecla. The Hecla returned to England reaching it in October 1825.
After marrying Louisa Stanley in October 1826, and having been given permission from the Admiralty, Parry set off for his last expedition in 1827 for an attempt on the North Pole from the northern shores of Spitsbergen at Sjuoyane. He reached 82 degrees 45 N which remained the highest latitude attained for the next 49 years and published an account of this journey under the title of 'Narrative of the Attempt to reach the North Pole.'